cfd inhibitor danicopan Search Results


cfd inhibitor danicopan  (MedChemExpress)
93
MedChemExpress cfd inhibitor danicopan
( a ) BLI post transplantation. Presumptive FAPs (CD56 - CD90 + ) were purified by FACS from three mouse lemurs, transduced with a lentivirus expressing GFP and Luciferase, and transplanted into TA muscles of NSG recipient mice. Mice were imaged over time and normalized BLI signal was plotted as the mean plus standard error. n=17 from 3 donors. ( b ) Freshly isolated FAPs (top panels) or MuSCs (bottom panels) from mouse, lemur, or human were transplanted into the TA muscles of NSG mice. One month post transplantation, muscles were harvested, fixed, and frozen. Cryosections were stained with Oil Red O (ORO). ( c ) Quantification of ORO stains shown in (b). n=4. ( d-f ) Freshly isolated FAPs were expanded in vitro and treated with differentiation media for adipogenic (d), fibrogenic (e), or osteogenic (f) conversion. Cells were stained for Perilipin-1 (d), SMA (e), or RUNX2 (f). Left panels show representative images, right panels show graphs of quantification. n=3 biological independent samples. ( g ) Freshly isolated FAPs were stained for <t>CFD</t> protein levels. Left panels show representative images, right panel shows graph of quantifications (n=3). ( h ) Freshly isolated FAPs were transduced with luciferase expressing lentivirus. Half of the cells were simultaneously treated with the CFD inhibitor <t>Danicopan</t> or vehicle (Ctrl). Cells were transplanted into the TA muscles of three recipient NSG mice. Engraftment was monitored by BLI. n=6 from 2 donors. ( i ) Transplanted muscles from (h) were isolated, fixed, and stained for ORO. Left panels show representative images with arrow heads denoting ORO staining, right panels show graphs of quantification. n=3.
Cfd Inhibitor Danicopan, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cfd inhibitor ach 4471  (Selleck Chemicals)
92
Selleck Chemicals cfd inhibitor ach 4471
( a ) BLI post transplantation. Presumptive FAPs (CD56 - CD90 + ) were purified by FACS from three mouse lemurs, transduced with a lentivirus expressing GFP and Luciferase, and transplanted into TA muscles of NSG recipient mice. Mice were imaged over time and normalized BLI signal was plotted as the mean plus standard error. n=17 from 3 donors. ( b ) Freshly isolated FAPs (top panels) or MuSCs (bottom panels) from mouse, lemur, or human were transplanted into the TA muscles of NSG mice. One month post transplantation, muscles were harvested, fixed, and frozen. Cryosections were stained with Oil Red O (ORO). ( c ) Quantification of ORO stains shown in (b). n=4. ( d-f ) Freshly isolated FAPs were expanded in vitro and treated with differentiation media for adipogenic (d), fibrogenic (e), or osteogenic (f) conversion. Cells were stained for Perilipin-1 (d), SMA (e), or RUNX2 (f). Left panels show representative images, right panels show graphs of quantification. n=3 biological independent samples. ( g ) Freshly isolated FAPs were stained for <t>CFD</t> protein levels. Left panels show representative images, right panel shows graph of quantifications (n=3). ( h ) Freshly isolated FAPs were transduced with luciferase expressing lentivirus. Half of the cells were simultaneously treated with the CFD inhibitor <t>Danicopan</t> or vehicle (Ctrl). Cells were transplanted into the TA muscles of three recipient NSG mice. Engraftment was monitored by BLI. n=6 from 2 donors. ( i ) Transplanted muscles from (h) were isolated, fixed, and stained for ORO. Left panels show representative images with arrow heads denoting ORO staining, right panels show graphs of quantification. n=3.
Cfd Inhibitor Ach 4471, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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danicopan (alxn2040  (Alexion Phrama)
90
Alexion Phrama danicopan (alxn2040
( a ) BLI post transplantation. Presumptive FAPs (CD56 - CD90 + ) were purified by FACS from three mouse lemurs, transduced with a lentivirus expressing GFP and Luciferase, and transplanted into TA muscles of NSG recipient mice. Mice were imaged over time and normalized BLI signal was plotted as the mean plus standard error. n=17 from 3 donors. ( b ) Freshly isolated FAPs (top panels) or MuSCs (bottom panels) from mouse, lemur, or human were transplanted into the TA muscles of NSG mice. One month post transplantation, muscles were harvested, fixed, and frozen. Cryosections were stained with Oil Red O (ORO). ( c ) Quantification of ORO stains shown in (b). n=4. ( d-f ) Freshly isolated FAPs were expanded in vitro and treated with differentiation media for adipogenic (d), fibrogenic (e), or osteogenic (f) conversion. Cells were stained for Perilipin-1 (d), SMA (e), or RUNX2 (f). Left panels show representative images, right panels show graphs of quantification. n=3 biological independent samples. ( g ) Freshly isolated FAPs were stained for <t>CFD</t> protein levels. Left panels show representative images, right panel shows graph of quantifications (n=3). ( h ) Freshly isolated FAPs were transduced with luciferase expressing lentivirus. Half of the cells were simultaneously treated with the CFD inhibitor <t>Danicopan</t> or vehicle (Ctrl). Cells were transplanted into the TA muscles of three recipient NSG mice. Engraftment was monitored by BLI. n=6 from 2 donors. ( i ) Transplanted muscles from (h) were isolated, fixed, and stained for ORO. Left panels show representative images with arrow heads denoting ORO staining, right panels show graphs of quantification. n=3.
Danicopan (Alxn2040, supplied by Alexion Phrama, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


( a ) BLI post transplantation. Presumptive FAPs (CD56 - CD90 + ) were purified by FACS from three mouse lemurs, transduced with a lentivirus expressing GFP and Luciferase, and transplanted into TA muscles of NSG recipient mice. Mice were imaged over time and normalized BLI signal was plotted as the mean plus standard error. n=17 from 3 donors. ( b ) Freshly isolated FAPs (top panels) or MuSCs (bottom panels) from mouse, lemur, or human were transplanted into the TA muscles of NSG mice. One month post transplantation, muscles were harvested, fixed, and frozen. Cryosections were stained with Oil Red O (ORO). ( c ) Quantification of ORO stains shown in (b). n=4. ( d-f ) Freshly isolated FAPs were expanded in vitro and treated with differentiation media for adipogenic (d), fibrogenic (e), or osteogenic (f) conversion. Cells were stained for Perilipin-1 (d), SMA (e), or RUNX2 (f). Left panels show representative images, right panels show graphs of quantification. n=3 biological independent samples. ( g ) Freshly isolated FAPs were stained for CFD protein levels. Left panels show representative images, right panel shows graph of quantifications (n=3). ( h ) Freshly isolated FAPs were transduced with luciferase expressing lentivirus. Half of the cells were simultaneously treated with the CFD inhibitor Danicopan or vehicle (Ctrl). Cells were transplanted into the TA muscles of three recipient NSG mice. Engraftment was monitored by BLI. n=6 from 2 donors. ( i ) Transplanted muscles from (h) were isolated, fixed, and stained for ORO. Left panels show representative images with arrow heads denoting ORO staining, right panels show graphs of quantification. n=3.

Journal: bioRxiv

Article Title: In vivo self-renewal and expansion of quiescent stem cells from a non-human primate

doi: 10.1101/2025.03.27.645793

Figure Lengend Snippet: ( a ) BLI post transplantation. Presumptive FAPs (CD56 - CD90 + ) were purified by FACS from three mouse lemurs, transduced with a lentivirus expressing GFP and Luciferase, and transplanted into TA muscles of NSG recipient mice. Mice were imaged over time and normalized BLI signal was plotted as the mean plus standard error. n=17 from 3 donors. ( b ) Freshly isolated FAPs (top panels) or MuSCs (bottom panels) from mouse, lemur, or human were transplanted into the TA muscles of NSG mice. One month post transplantation, muscles were harvested, fixed, and frozen. Cryosections were stained with Oil Red O (ORO). ( c ) Quantification of ORO stains shown in (b). n=4. ( d-f ) Freshly isolated FAPs were expanded in vitro and treated with differentiation media for adipogenic (d), fibrogenic (e), or osteogenic (f) conversion. Cells were stained for Perilipin-1 (d), SMA (e), or RUNX2 (f). Left panels show representative images, right panels show graphs of quantification. n=3 biological independent samples. ( g ) Freshly isolated FAPs were stained for CFD protein levels. Left panels show representative images, right panel shows graph of quantifications (n=3). ( h ) Freshly isolated FAPs were transduced with luciferase expressing lentivirus. Half of the cells were simultaneously treated with the CFD inhibitor Danicopan or vehicle (Ctrl). Cells were transplanted into the TA muscles of three recipient NSG mice. Engraftment was monitored by BLI. n=6 from 2 donors. ( i ) Transplanted muscles from (h) were isolated, fixed, and stained for ORO. Left panels show representative images with arrow heads denoting ORO staining, right panels show graphs of quantification. n=3.

Article Snippet: The CFD inhibitor Danicopan (MedChem Express, Cat no. HY-117930) was dissolved in DMSO (BP231, Fisher Scientific) and added to the adipogenic medium at a final concentration of 1 mM and replenished every 2 days for two weeks.

Techniques: Transplantation Assay, Purification, Transduction, Expressing, Luciferase, Muscles, Isolation, Staining, In Vitro